The thioredoxin system of Plasmodium falciparum and other parasites
Identifieur interne : 002178 ( Main/Exploration ); précédent : 002177; suivant : 002179The thioredoxin system of Plasmodium falciparum and other parasites
Auteurs : S. Rahlfs [États-Unis] ; R. H. Schirmer [États-Unis] ; K. Becker [États-Unis]Source :
- Cellular and Molecular Life Sciences CMLS [ 1420-682X ] ; 2002-06-01.
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Abstract
Abstract:: Antioxidant defence plays a crucial role in rapidly growing and multiplying organisms, including parasites and tumor cells. Apart from reactive oxygen species (ROS) produced in endogenous reactions, parasites are usually exposed to high ROS concentrations imposed by the host immune system. The glutathione and thioredoxin systems represent the two major antioxidant defence lines in most eukaryotes and prokaryotes. Trypanosomatids, however, are characterized by their unique trypanothione system. These systems are NADPH-dependent and based on the catalytic activity of the flavoenzymes glutathione reductase, trypanothione reductase and thioredoxin reductase (TrxR), respectively. TrxR reduces the 12-kDa protein thioredoxin (Trx), which in turn provides electrons to ribonucleotide reductase, thioredoxin peroxidases (TPxs), certain transcription factors and other target molecules. Comparing the thioredoxin systems of different parasites and their respective host cells enhances our understanding of parasite biology and evolution, of parasite-host interactions and mechanisms of drug resistance. It furthermore opens avenues for the development of novel antiparasitic compounds. Here we review the current knowledge on the Trx systems of eukaryotic parasites, finally focusing on the malarial parasite Plasmodium falciparum.
Url:
DOI: 10.1007/s00018-002-8484-9
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Rahlfs</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Delaware</region></placeName><wicri:cityArea>Interdisciplinary Research Center, Gießen University, Heinrich-Buff-Ring 26–32, 35392 Gießen (Germany) Fax + 49 (0)641 9939129, e-mail: becker.katja@gmx.de</wicri:cityArea></affiliation></author><author><name sortKey="Schirmer, R H" sort="Schirmer, R H" uniqKey="Schirmer R" first="R. H." last="Schirmer">R. H. Schirmer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Delaware</region></placeName><wicri:cityArea>Biochemistry Center, Ruprecht-Karls-University, Heidelberg, Germany</wicri:cityArea></affiliation></author><author><name sortKey="Becker, K" sort="Becker, K" uniqKey="Becker K" first="K." last="Becker">K. Becker</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Delaware</region></placeName><wicri:cityArea>Interdisciplinary Research Center, Gießen University, Heinrich-Buff-Ring 26–32, 35392 Gießen (Germany) Fax + 49 (0)641 9939129, e-mail: becker.katja@gmx.de</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Cellular and Molecular Life Sciences CMLS</title><title level="j" type="abbrev">CMLS, Cell. Mol. Life Sci.</title><idno type="ISSN">1420-682X</idno><idno type="eISSN">1420-9071</idno><imprint><publisher>Birkhäuser Verlag</publisher><pubPlace>Basel</pubPlace><date type="published" when="2002-06-01">2002-06-01</date><biblScope unit="volume">59</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1024">1024</biblScope><biblScope unit="page" to="1041">1041</biblScope></imprint><idno type="ISSN">1420-682X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1420-682X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Key words: Thioredoxin; thioredoxin reductase; malaria; peroxiredoxin; Plasmodium falciparum.</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract:: Antioxidant defence plays a crucial role in rapidly growing and multiplying organisms, including parasites and tumor cells. Apart from reactive oxygen species (ROS) produced in endogenous reactions, parasites are usually exposed to high ROS concentrations imposed by the host immune system. The glutathione and thioredoxin systems represent the two major antioxidant defence lines in most eukaryotes and prokaryotes. Trypanosomatids, however, are characterized by their unique trypanothione system. These systems are NADPH-dependent and based on the catalytic activity of the flavoenzymes glutathione reductase, trypanothione reductase and thioredoxin reductase (TrxR), respectively. TrxR reduces the 12-kDa protein thioredoxin (Trx), which in turn provides electrons to ribonucleotide reductase, thioredoxin peroxidases (TPxs), certain transcription factors and other target molecules. Comparing the thioredoxin systems of different parasites and their respective host cells enhances our understanding of parasite biology and evolution, of parasite-host interactions and mechanisms of drug resistance. It furthermore opens avenues for the development of novel antiparasitic compounds. Here we review the current knowledge on the Trx systems of eukaryotic parasites, finally focusing on the malarial parasite Plasmodium falciparum.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Delaware</li></region></list><tree><country name="États-Unis"><region name="Delaware"><name sortKey="Rahlfs, S" sort="Rahlfs, S" uniqKey="Rahlfs S" first="S." last="Rahlfs">S. Rahlfs</name></region><name sortKey="Becker, K" sort="Becker, K" uniqKey="Becker K" first="K." last="Becker">K. Becker</name><name sortKey="Schirmer, R H" sort="Schirmer, R H" uniqKey="Schirmer R" first="R. H." last="Schirmer">R. H. Schirmer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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